Kev tshawb fawb tsis ntev los no ntawm urokinase, tus neeg sawv cev thrombolytic, tau tshawb nrhiav ntau yam kev siv tshiab thiab cov txheej txheem uas tuaj yeem txhim kho nws cov txiaj ntsig kho mob thiab nthuav dav nws cov txiaj ntsig kho mob.
1. Nanomicrosphere Sustained-Release Systems
Ib qho kev cog lus ntawm kev tshawb fawb muaj xws li kev txhim kho ntawm nanomicrosphere sustained-tso systems rau urokinase tus me nyuam. Cov tshuab no siv cov ntaub ntawv biocompatible los encapsulate urokinase, tso cai rau kev tswj hwm thiab ncua ntev ntawm cov tshuaj. Txoj hauv kev no tau pom tias muaj peev xwm kho cov hlab ntsha sib sib zog nqus (DVT) tau zoo dua los ntawm kev tswj xyuas cov qib urokinase nyob rau lub sijhawm ntev, uas tuaj yeem txhim kho cov txiaj ntsig ntawm tus neeg mob thiab txo qhov zaus ntawm kev tswj hwm 【Rsc Publishing】.
2. Molecular Imaging ntawm uPAR
Lwm qhov kev nce qib tseem ceeb yog nyob rau hauv cov duab molecular ntawm urokinase plasminogen activator receptor (uPAR). Kev tshawb fawb tau pom tias uPAR ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem ntawm tes, suav nrog kev tsiv teb tsaws, adhesion, thiab proteolysis, uas yog qhov tseem ceeb hauv ob qho tib si physiological thiab pathological mob xws li mob thiab mob qog noj ntshav. Los ntawm kev tsom mus rau uPAR, cov kws tshawb fawb tsom los tsim cov txheej txheem kev yees duab meej dua uas tuaj yeem txheeb xyuas cov kab mob atherosclerotic plaques, yog li txhim kho kev kuaj mob thiab tswj cov kab mob plawv 【SpringerOpen】.
3. Kev kho mob ko taw mob plab
Urokinase daim ntawv thov hauv kev kho mob ntshav qab zib ko taw ulcers (DFUs) kuj tau tshawb xyuas. Ib txoj kev tshawb fawb tau soj ntsuam qhov ua tau zoo ntawm kev nruam intrafemoral artery infusion ntawm low-dose urokinase hauv cov neeg mob nrog DFUs. Cov txiaj ntsig tau qhia txog kev txhim kho hauv kev kho mob ntawm qhov txhab thiab txo qis hauv cov hlab plawv, qhia tias urokinase tuaj yeem muab cov kev kho mob muaj txiaj ntsig zoo hauv kev tswj cov teeb meem ntshav qab zib 【Rsc Publishing】.
4. Kev Kho Mob Cancer
Tshaj li nws cov kev siv ib txwm siv hauv thrombolysis, urokinase tau tshawb nrhiav rau nws lub peev xwm hauv kev kho mob qog noj ntshav. Lub urokinase plasminogen activator system yog koom nrog hauv cov qog nqaij hlav thiab metastasis. Los ntawm inhibiting cov txheej txheem no, cov kws tshawb fawb vam tias yuav tsim kho mob qog noj ntshav tshiab uas tiv thaiv kev kis tus kabmob malignant. Cov kev tshawb fawb tau tsom mus rau yuav ua li cas urokinase thiab nws cov receptor kev sib cuam tshuam tuaj yeem hloov kho los cuam tshuam kev mob qog noj ntshav 【SpringerOpen】.
Cov lus qhia kev tshawb fawb no qhia txog qhov muaj peev xwm thiab muaj peev xwm ntawm urokinase tshaj nws cov kev siv ib txwm siv. Los ntawm leveraging advanced delivery systems, molecular imaging, thiab tshawb nrhiav cov ntsiab lus kho tshiab, cov kws tshawb fawb tab tom txhim kho txoj hauv kev kom muaj txiaj ntsig zoo dua thiab tsom mus rau kev kho mob siv urokinase.