Trilostane, cov tshuaj hluavtaws enzyme inhibiting, tau hloov kho kev kho mob ntawm Cushing's Disease (hyperadrenocorticism) hauv dev thiab miv. Cov tshuaj no ua haujlwm los ntawm kev txo qis cov tshuaj cortisol ntau dhau los ntawm cov qog adrenal, tswj cov tsos mob ntawm tus mob no.
Indications thiab Administration
Trilostane feem ntau yog siv los kho cov kab mob pituitary-dependent Cushing's Disease, feem ntau hauv cov dev, nrog rau adrenal-dependent Cushing's thiab alopecia X. Nws yog siv los ntawm qhov ncauj raws li tshuaj ntsiav, feem ntau nrog zaub mov, thiab nws cov teebmeem tuaj yeem pom hauv 1. mus rau 2 hnub. Kev saib xyuas tsis tu ncua nrog ACTH stimulation tests yog qhov tseem ceeb los xyuas kom meej tias cov koob tshuaj yog qhov tsim nyog thiab saib xyuas qhov tsis zoo.
Kev ua tau zoo thiab tus nqi ciaj sia
Ntau cov ntawv tshawb fawb tau lees paub qhov kev nyab xeeb thiab kev ua tau zoo ntawm trilostane hauv kev kho Cushing's Disease. Ib txoj kev tshawb fawb tsis ntev los no tau tshaj tawm tias cov dev uas tsis kho pituitary-dependent Cushing's tau luv luv lub sij hawm ciaj sia taus (506 hnub) piv rau cov neeg kho nrog trilostane ntawm 1 mus rau 3 mg / kg ib zaug lossis ob zaug ib hnub, uas lub sij hawm muaj sia nyob nruab nrab tsis tau txog thaum kawg. txoj kev kawm.
Muaj peev xwm cuam tshuam thiab saib xyuas
Thaum feem ntau ua tau zoo, cov kev mob tshwm sim ntawm trilostane tuaj yeem suav nrog kev qaug zog, ntuav, raws plab, thiab tsis qab los noj mov, tshwj xeeb tshaj yog thaum thawj ob peb hnub ntawm kev kho. Nyob rau hauv tsawg zaus, ib qho kev hem thawj rau lub neej hu ua Addisonian ntsoog tuaj yeem tshwm sim. Cov tsiaj yuav tsum tau saib xyuas kom ze rau cov tsos mob xws li ntuav, raws plab, qaug zog, tshee, haus dej ntau ntxiv lossis tso zis, qaug zog, lossis qaug zog.
Muaj thiab Formulations
Trilostane muaj nyob rau hauv ntau hom tshuaj, nrog rau cov tshuaj tsw qab hauv qhov ncauj, tshuaj noj hauv qhov ncauj hauv gelatin lossis veggie capsules, thiab cov dej hauv qhov ncauj tshem tawm nrog ntau yam kev xaiv flavoring. Nws yuav tsum tau muab khaws cia rau hauv cov thawv nruj, lub teeb-tiv taus ntawm chav tsev kub.Nyob rau hauv cov ntsiab lus, trilostane tau hloov kho cov kev kho mob ntawm Cushing's Disease hauv cov dev thiab miv los ntawm kev txo qis cortisol ntau dhau thiab txhim kho cov ciaj sia taus. Thaum nws yuav tsum tau saib xyuas los ntawm tus kws kho tsiaj, trilostane tau dhau los ua ib qho tseem ceeb hauv kev tswj hwm qhov kev nyuaj no.