Corey lactone diol, tseem hu ua (-)-Corey lactone diol, yog cov tshuaj sib xyaw nrog cov mis molecular C8H12O4. Nws yog ib qho kev txo qis ntawm Corey aldehyde, featuring cawv pawg ntawm C-11 thiab C-13. Cov qauv no tso cai rau kev taw qhia ntawm ω chain constituents los ntawm alternate chemistry, xws li nucleophilic displacements.
Corey lactone diol yog soluble nyob rau hauv ntau yam organic solvents, xws li ethanol, DMSO, thiab dimethyl formamide, nrog solubility theem ntawm kwv yees li 10, 30, thiab 50 mg / ml, raws li [1]. Nws tuaj yeem khaws cia rau hauv chav tsev kub thiab yuav nyob ruaj khov rau tsawg kawg ob xyoos [1]. Lub compound yog muaj nyob rau hauv crystalline khoom thiab yuav yaj nyob rau hauv cov organic solvents purged nrog ib tug inert roj los tsim ib tug Tshuag tov. Ntxiv dilutions rau hauv aqueous buffers los yog isotonic saline yuav tsum tau ua ua ntej mus rau kev sim tshuaj lom neeg.
Corey lactone diol ua hauj lwm raws li ib tug ntau yam intermediate nyob rau hauv lub synthesis ntawm prostaglandins thiab prostaglandin analogs. Nws yog siv los npaj prostaglandin derivatives nrog kev hloov kho hauv cov saw hlau, ω saw, los yog ob qho tib si, uas nkag tau yooj yim los ntawm Corey lactone diol.
Lub compound kuj tseem siv rau hauv ntau yam kev tshawb fawb daim ntawv thov, nrog rau kev sib txuas ntawm cov tshuaj sib txuas, cov khoom ntuj tsim, thiab tshuaj tua kab. Nws solubility nyob rau hauv cov kuab tshuaj organic ua rau nws haum rau siv nyob rau hauv ntau yam tshuaj tiv thaiv thiab synthesis txheej txheem.
Hauv cov ntsiab lus, Corey lactone diol yog ib qho tseem ceeb nruab nrab ntawm kev sib txuas ntawm prostaglandins thiab prostaglandin analogs, nrog rau kev siv tshuaj hauv kev tshawb fawb thiab kev sib txuas. Nws solubility nyob rau hauv cov organic solvents thiab stability nyob rau hauv lub sij hawm ua rau nws yog ib qho tseem ceeb cuab tam nyob rau hauv ntau yam tshuaj tiv thaiv thiab synthesis txheej txheem.