Neostigmine methylsulfate txhaj tshuaj

Khoom Specifications

Lub Npe

Cov khoom xyaw tseem ceeb

Neostigmine methyl sulfate

Cov khoom

Cov khoom no yog xim tsis muaj xim, ntshiab kua.

Specification

5ml: 5mg, 1ml: 1mg, 10ml: 10mg

Pob

10pcs / thawv

Kev siv thiab ntau npaum

▸ Intramuscular lossis subcutaneous txhaj tshuaj:Ib koob: Nees 4-10ml; 4-20 ml; Yaj thiab npua 2-5ml; Yog '0.25-1 ml.

Cov tshuaj sib cuam tshuam

▸ Cov khoom no tuaj yeem ua kom ntev thiab txhim kho cov leeg nqaij so ntawm depolarizing succinylcholine chloride.

▸Nws muaj cov nyhuv antagonistic nrog tsis yog -depolarizing cov leeg nqaij so.

Pharmacological teebmeem

Neostigmine inhibits cholinesterase kev ua haujlwm, tiv thaiv hydrolysis ntawm acetylcholine thiab nce nws cov concentration hauv lub cev, yog li txhim kho thiab ua kom nws cov nyhuv ntev. Neostigmine muaj zog stimulating nyhuv ntawm cov nqaij ntshiv ntawm txoj hnyuv, zais zis, thiab lub tsev me nyuam, tab sis ib tug qaug zog stimulating nyhuv ntawm glandular, iris, thiab bronchial du nqaij, thiab ib tug tsis muaj zog inhibitory nyhuv ntawm cov hlab plawv system; nws cov nyhuv ntawm lub hauv paus paj hlwb tsis tseem ceeb. Neostigmine muaj qhov muaj zog tshaj plaws ntawm cov leeg pob txha. Qhov no skeletal leeg stimulation yog txuam tsis tau tsuas yog rau nws inhibition ntawm cholinesterase tab sis kuj mus rau nws ncaj qha stimulation ntawm N2 receptors nyob rau hauv lub engine endplates thiab nws nce qib ntawm acetylcholine tso tawm ntawm lub cev muaj zog paj hlwb xaus. Neostigmine yog absorbed tsis zoo ntawm qhov ncauj thiab tsis yooj yim hla cov ntshav - hlwb teeb meem. Nws cov plasma protein khi tus nqi yog 15% -25%. Hauv lub cev, qee cov tshuaj yog hydrolyzed los ntawm plasma cholinesterase thiab tawm hauv cov zis raws li quaternary ammonium alcohols thiab cov tshuaj tsis hloov pauv. Ib feem metabolized los ntawm lub siab yog tawm los ntawm cov kua tsib duct.

Kev phiv tshuaj

Cov koob tshuaj kho mob muaj ob peb yam tshwm sim. Kev siv tshuaj ntau dhau tuaj yeem ua rau tawm hws, bradycardia, cov leeg tremors, lossis cov leeg leeg tuag tes tuag taw.

Muaj nuj nqi thiab kev siv

Cov tshuaj cholinergic. Feem ntau siv rau plab hnyuv atony, myasthenia gravis, thiab khaws cia placenta.

Cov kev ceev faj

▸ Cov khoom no yog contraindicated nyob rau hauv cov tsiaj nrog mechanical plab hnyuv obstruction los yog bronchial hawb pob.

▸ Atropine tuaj yeem siv los tiv thaiv nws cov nyhuv excitatory ntawm M receptors thaum muaj tshuaj lom.

▸ Cov khoom no tuaj yeem ua kom ntev thiab txhim kho cov leeg nqaij so ntawm depolarizing succinylcholine chloride, thiab muaj cov nyhuv antagonistic nrog tsis yog -depolarizing cov leeg nqaij so.